• DRB: Mechanisms and Applications in Transcriptional Elong...

  2025-09-23

  Explore the scientific underpinnings and research applications of 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole (DRB), a potent transcriptional elongation inhibitor and CDK inhibitor, in HIV and antiviral research. This article provides a rigorous, evidence-based overview of DRB's role in modulating RNA polymerase II activity and cell cycle regulation.

• Vorinostat in Cancer Research: HDAC Inhibition, Chromatin...

  2025-09-22

  Vorinostat (suberoylanilide hydroxamic acid) is a potent histone deacetylase inhibitor for cancer research, enabling detailed studies of epigenetic modulation and apoptotic mechanisms. This article explores its unique role in chromatin remodeling and discusses recent findings that link HDAC inhibition to mitochondrial apoptosis beyond gene expression changes.

• MG-132 in Proteostasis and Cellular Stress: New Insights ...

  2025-09-19

  Explore how MG-132, a potent cell-permeable proteasome inhibitor peptide aldehyde, advances research on apoptosis, cell cycle arrest, and proteostasis. This article highlights novel applications of MG-132 in studying oxidative stress and autophagy, with emphasis on modeling neurodegenerative disease mechanisms.

• Protease Inhibitor Cocktail EDTA-Free: Advancing Protein ...

  2025-09-18

  Explore how the Protease Inhibitor Cocktail (EDTA-Free, 100X in DMSO) enables precise protein extraction by preserving native protein function and post-translational modifications, making it ideal for sensitive downstream applications such as phosphorylation analysis.

• VX-765 The take home message here is that although

  2025-04-21

  

  The take-home message here is that, although Aurora A phosphorylated on T288 is the activated isoform of Aurora A, measuring the level of phosphorylation of T288 does not reflect Aurora A kinase activity (Figure 5). What would be the most appropriate readout for an in vivo Aurora A kinase activity

• As cytosolic acetyl CoA levels in hepatocytes

  2025-04-19

  

  As cytosolic acetyl-CoA levels in hepatocytes descend, cellular production and concentration of cholesterol go down, a change that is known to be sensed by the Sterol response element binding protein (SREBP)/Cleavage-Activating Protein system, leading to SREBP escort to the Golgi apparatus, cleavage

• br Acknowledgment Supported in part by NIH R

  2025-04-15

  

  Acknowledgment Supported in part by NIH1R21EB012707 (Biegon, Anat PI). Introduction Estrogens exert pleiotropic effects on a variety of morphological, physiological and behavioral responses in all vertebrate classes ranging from fishes to mammals. Effects of estrogens in the Prestained Protei

• Secondly leptin has been shown to enhance aromatase mRNA exp

  2025-04-14

  

  Secondly, leptin has been shown to enhance aromatase mRNA expression, aromatase content and its enzymatic activity in epithelial breast cancer Biotin-tyramide by inducing promoters II and I.3 via an enhanced binding of transcription activator protein 1 (AP-1) complex to specific DNA sites in the pro

• br Conflicts of interest br Introduction Arginase catalyzes

  2025-04-12

  

  Conflicts of interest Introduction Arginase catalyzes the reaction in which l-arginine is converted to l-ornithine and urea. In humans, two arginase isoenzymes have been identified, arginase 1 and arginase 2, that differ in cellular location and tissue distribution [1]. Both arginase enzymes a

• In our previous report salivary arginase levels were found t

  2025-04-12

  

  In our previous report, salivary arginase levels were found to be higher in periodontitis patients compared to healthy controls (Ozmeriç, Elgün, & Uraz, 2000). However, only one study has investigated arginase ezyme in saliva in patients with dental implants in which smokers were also included. An i

• br Experimental br Acknowledgment This

  2025-04-11

  

  Experimental Acknowledgment This paper was financially supported by the Project Funded by China Postdoctoral Science Foundation (2017T100186), Natural Science Foundation of Liaoning Province (20170540858), General Scientific Research Projects of Department of Education of Liaoning Province (20

• br Funding The present study was funded by The

  2025-04-11

  

  Funding The present study was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) within Research Program 1001, unique project number: 214S349. Introduction The apelin receptor, also called APJ or angiotensin receptor-like 1 was first cloned in 1993 due to its stro

• To better illustrate the involved neuronal postganglionic pa

  2025-04-11

  

  To better illustrate the involved neuronal postganglionic pathways, central apelin-13 injection was performed in rats received peripheral preadministration of NOS inhibitor L-NAME, sympatholytic agent guanethidine and/or muscarinic receptor agonist bethanechol. Compared with the rats received vehicl

• Introduction The corpus luteum CL is a transient endocrine g

  2025-04-10

  

  Introduction The corpus luteum (CL) is a transient endocrine gland that differentiates from the thecal and granulosal cells of the ovarian follicle after ovulation. Its formation and limited lifespan in the mammalian ovary is important for fertility, as the CL produces progesterone (P4), the essent

• The transcription factor activator protein AP is a

  2025-04-10

  

  The transcription factor activator protein-1 (AP-1) is a redox-sensitive transcription factor whose activity is controlled by agents that perturb intracellular thiol concentrations [10,11]. AP-1 is mainly composed of Jun, Fos, and ATF protein dimers [12,13]. AP-1 mediates the regulation of numerous

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