• Preliminary studies evidenced the presence of CRFr in gamma

  2019-10-16

  

  Preliminary studies evidenced the presence of CRFr in gamma-aminobutyric acid-ergic (GABAergic) neurons of the hippocampus (Yan et al., 1998). In fact, in this biotin products area, CRF inhibits glutamate release through CRF1r (Bagosi et al., 2015), leading to a decrease in the GABA concentration i

• As the communications interface was

  2019-10-16

  

  As the communications interface was developed by two separate organisations with differing software processes and tools, a modular approach to the safety case was deemed appropriate. The modular approach related the communications interface safety argument to the safety arguments for both the ACS an

• Moreover as shown in Fig f

  2019-10-16

  

  Moreover, as shown in Fig. 5f, while the knockdown of SMURF2 in wild-type AICAR phosphate kinase has no significant effect on HSP27, in CK2α/α′(−/−) cells it leads to an increase of HSP27 level. These results suggest that SMURF2 affects HSP27 protein stability only when overexpressed, at least in o

• br Acetylcholinesterase and cholinergic signaling The concep

  2019-10-16

  

  Acetylcholinesterase and cholinergic signaling The concept of a synapse between a neuron and an innervated cell, and the receptors that mediated their interaction, was developed by Bernard, Ehrlich, Sherrington, Langley and others (see [7], [8], [9]. It was long debated whether transmission of ne

• br In patients with type

  2019-10-16

  

  In patients with type I diabetes mellitus poor management causes/INS; a drastic rise in glucose levels resulting in diabetic ketoacidosis (DKA). About 1% of DKA episodes can be complicated by cerebral edema. ET and its receptors are involved in the regulation of /INS;cerebral blood flow. We studie

• Bioinformatics analysis for genes encoding

  2019-10-16

  

  Bioinformatics analysis for genes encoding proteins (ESR1, IL6, TERT, DNMT3B) showed that NF-kB is one of the transcription factors that might be regulating their expression, especially for IL6, TERT and DNMT3B genes. Previous studies have demonstrated that PA induces NF-kB activation, thus increasi

• br Results br Discussion In

  2019-10-16

  

  Results Discussion In this study, we investigated the role of EP4 on invasion and invadopodia in breast cancer cells. Our results demonstrate that EP4 activation promotes invadopodia-driven ECM degradation, in turn facilitating future intravasation and metastasis of breast cancer jsh mass (Gl

• br Conflict of interest statement br Introduction Endothelin

  2019-10-15

  

  Conflict of interest statement Introduction Endothelins (ETs) are a family of multifunctional, naturally occurring peptides with long-lasting vasoconstrictor and pressor effects (Zhou et al., 2004). They are synthesized as a large protein, the pre-proET-1 or Big ET-1, which is subsequently cle

• Interestingly our analyses of human PBMCs

  2019-10-15

  

  Interestingly, our analyses of human PBMCs using a monoclonal antibody against EBI2 showed that the expression pattern of human EBI2 is largely overlapping with that in mice. Especially Th17 nhs chemical showed homogeneous high expression of EBI2 compared with Th1 cells, which contained a fraction

• br Introduction Vitis vinifera L is

  2019-10-15

  

  Introduction Vitis vinifera L. is one of the most worldwide-grown fruit crop and is mostly used in the wine industry (Bouquet, 2011). Domestication and history changed dramatically the biology of this species and today there are thousands of V. vinifera varieties, being many of them closely relat

• br Introduction In most of

  2019-10-15

  

  Introduction In most of the angiosperms, sexual reproduction requires a process called double fertilization where the specialized cell division called meiosis produces haploid gametes combine to form diploid (2n) embryo. In Prote pathway to this, apomixis, naturally occurs in at least 400 plant f

• Dehydrogenation by a KSTD is also a

  2019-10-15

  

  — 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during neurotensin receptor degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of both aerobic and anaerobic st

• It is well known that corticotropin releasing

  2019-10-15

  

  It is well-known that corticotropin-releasing factor (CRF) exerts its biological functions through binding to type-1 (CRF1) and/or type-2 (CRF2) receptors. Several clinical evidences suggest the association of a high level of CRF and the onset of anxiety and depressive disorders.2, 3, 4, 5, 6, 7 Si

• Allele specific methylation has been observed in CpG

  2019-10-15

  

  Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL pp3 kinase and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the same patients.

• cathepsin inhibitors Sensory gating describes a filter

  2019-10-15

  

  ‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits cathepsin inhibitors to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003

14152 records 903/944 page Previous Next First page 上5页 901902903904905 下5页 Last page