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MOG (35-55) br Introduction Receptor tyrosine kinases RTKs a
2021-03-27
Introduction Receptor tyrosine kinases (RTKs) are critically involved in the development and progression of human cancers and are therefore useful targets for anti-cancer therapies [1]. The Eph receptors represent the largest subfamily of receptor protein kinases and interact with ligands called
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It is without doubt that the vagina
2021-03-26
It is without doubt that the vagina plays a significant role in the perception of coital stimulation leading to sexual arousal and, finally, orgasm. In response to sensory stimulation, relaxation of vaginal vascular and nonvascular smooth muscle occurs, resulting in an increase in local blood flow a
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br Results and discussion br Conclusion Recent studies
2021-03-26
Results and discussion Conclusion Recent studies showed that EGFR signaling is involved in inflammatory response in several inflammatory conditions. The normal inflammatory macrophage CYC202 show EGFR-dependent production of inflammatory mediators. Nevertheless, the development of EGFR inhibi
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Several studies have indicated that ICT induces activation
2021-03-26
Several studies have indicated that ICT induces activation of ERK and p38 kinase in a variety of cells. The ERK pathway was involved in and partly contributed to the neuroprotective effects in rat neuronal Propylthiouracil [14] and anticancer effects in several cancer cells [5], [7], [8]. ICT could
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br Acknowledgements We thank Dr James Ritchie and his
2021-03-26
Acknowledgements We thank Dr. James Ritchie and his dedicated staff (Deptartment of Pathology, Emory University) for performing measures of serum VPA levels; Sumitomo Pharmaceuticals (Osaka, Japan) for the generous donation of DOPS, which is required for breeding Dbh −/− mice; Pfizer (Sandwich, K
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The kinase activity of DNA PKcs is essential for NHEJ
2021-03-26
The kinase activity of DNA-PKcs is essential for NHEJ, but the exact role of the enzymatic activity of DNA-PKcs plays in NHEJ is not fully understood [57]. In vitro, DNA-PKcs can phosphorylate each of the canonical NHEJ factors including Ku70/80 [58], [59], XRCC4 [60], [61], trp channels IV [62], a
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br Materials and methods br
2021-03-26
Materials and methods Results Discussion Cysteine proteases are upregulated under oxidative stress and play an important role in the preservation of cellular metabolism (Usui et al., 2007). Cysteine proteases are also important under abiotic stresses for plants to degrade proteins denatured
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Pleuromutilin receptor Although elevated production of cysLT
2021-03-26
Although elevated production of cysLTs is characteristic of rhinosinusitis of diverse etiology, patients with aspirin-sensitive rhinosinusitis show even higher levels of cysLTs in the nasal mucosa, which are further enhanced by aspirin challenge., Elevated production of cysLTs in these patients may
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Besides the enhanced expression of
2021-03-26
Besides the enhanced expression of costimulatory and adhesion proteins, also the expression of the CD83 surface molecule is strongly enhanced during DC maturation (Banchereau and Steinman 1998; Banchereau et al. 2000). In fact, CD83 is a major cell surface marker for fully mature DC, as it can not b
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Within their range of applicability both approaches
2021-03-26
Within their range of applicability, both approaches matched the phase boundaries and yields generally to within the measurement error. The approaches matched the phase compositions generally to within 11 wt% or less with the average absolute deviations listed below: One advantage of the proposed
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br Results Table shows demographics and clinical features of
2021-03-26
Results Table 1 shows demographics and clinical features of subjects with obesity and controls. Before surgery five obese were diabetic, only one on glucose-lowering therapy; three obese were dyslipidemic and assumed lipid lowering medications. Lathosterol levels were significantly higher in pati
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Enlarging the ligand binding pocket by reduction of the
2021-03-25
Enlarging the ligand-binding pocket by reduction of the size of the residue F435 switched DES to an agonist indicating that F435 is involved in mediating the antagonistic effect of DES (Fig. 7E) [13]. The conformation of the smaller side chain of L435 was either not altered by DES or was too small t
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Another clinical study indicated the daily consumption of gr
2021-03-25
Another clinical study indicated the daily consumption of green tea with low concentrations of theanine and catechin would improve cognitive function (Ide et al., 2014). Further, in a double blind randomized clinical study involving 102 patients, the Hypericum extract was examined in terms of effica
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Preliminary studies suggest that dimerization of the AT
2021-03-25
Preliminary studies suggest that dimerization of the AT1 receptor occurred during the biosynthesis in the endoplasmic reticulum before surface expression [27,40], which may explain the presenece of these VE821 synthesis before the addition of any ligand. Our results showed that the presence of Ang
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br Conflict of Interest br Statement of Authorship br
2021-03-25
Conflict of Interest Statement of Authorship Introduction Plant endopeptidases are involved in many important biological processes. Recent developments in molecular biological techniques have revealed trace amounts of endopeptidases play essential roles in plant development, turnover of pho
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