• br Acknowledgements We thank the

  2022-04-01

  

  Acknowledgements We thank the following individuals for notable contributions to this work: Dr. Ruth Wood, Dr. Alan Watts, Dr. Casey Donovan, Andrea Suarez, Emily Nakamoto, Allison Apfel, April Banayan, and Jonathan Cheung. This study was supported by the National Institute of Health grants, DK10

• Nicastrin is heavily glycosylated contributing KDa

  2022-04-01

  

  Nicastrin is heavily glycosylated, contributing 40–70KDa to the molecular weight of human γ-secretase. Among the 16 predicted N-linked glycosylation sites in the ECD, 11 have been unambiguously identified. The glycans appear to mostly stabilize the local structure, thus contributing to the folding a

• The conversion of lactose to GOS

  2022-04-01

  

  The conversion of lactose to GOS by β-gal involves the same transglycosylation mechanism used by most glycoside hydrolases (GHs). This mechanism (Fig. 1) involves an enzyme-bound intermediate and consists of two processes: glycosylation and deglycosylation (Adlercreutz, 2017). The glycosylation proc

• paricalcitol receptor br Acknowledgements We apologize to ou

  2022-04-01

  

  Acknowledgements We apologize to our distinguished colleagues whose work has not been cited owing to space limitations. This work was funded by the Italian Association for Cancer Research (AIRC, Milan, Italy, IG 14732 to A.M.); Italian Ministry of University and Education (Finanziamenti per la Ri

• Recent studies have elucidated a

  2022-04-01

  

  Recent studies have elucidated a profound role for FFA4 in modulation of metabolism and energy utilization as well as endocrine and immune function, and as a consequence, have thrust FFA4 to the forefront of drug discovery efforts. For example, activation of FFA4 by fatty TCS 5861528 or synthetic li

• In soft agar colony formation assay transformed cells indica

  2022-04-01

  

  In soft agar colony formation assay, transformed allopurinol zyloprim australia indicate anchorage-independent growth and colony formation without attachment on the bottom of cell culture plate. This assay can investigate transformation and tumorigenic activities [24]. Our recent study showed that t

• To explain the corporate debt

  2022-04-01

  

  To explain the corporate debt maturity, following Brockman et al. (2010), the time-varying control variables we include are: firm size (LSIZE), the square of firm size (LSIZE2), leverage (LEVERAGE), asset maturity (ASSET_MAT), managerial ownership (OWN), market-to-book ratio (MB), term structure of

• The primary cancer lesion was mostly

  2022-04-01

  

  The primary cancer lesion was mostly in the uterus and adnexa, followed by the gastrointestinal tract, brain, blood, and kidney and SCR 7 (Fig. 2A). Histopathological findings indicated that most cancers were adenocarcinomas, followed by squamous cell carcinomas, glioblastomas, malignant lymphomas,

• br Introduction It is well known that

  2022-04-01

  

  Introduction It is well known that conventional cancer treatment strategies, such as surgery, radiotherapy, and chemotherapy all have their own limitations, which lead to an unsatisfactory therapeutic effect. Under this situation, the combination of two or more therapeutic strategies has recently

• To date the crystal structures of

  2022-04-01

  

  To date, the crystal structures of HIV-1 IN complexed with ligands and related proteins could help us in studying the interactions between the inhibitors and IN. Until now, 114 co-crystal structures of HIV-1 IN with small molecular ligands 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34,

• br Materials and methods br

  2022-03-31

  

  Materials and methods Results Discussion Type I ECa is associated with estrogen excess, obesity and hormone-receptor positivity. However, the function of ERα on ECa is considered complicated. The expression of ERα is reduced in grade III ECa clinical samples [13]. The high ERα expression is

• Taken together the four HRs couple with

  2022-03-31

  

  Taken together, the four HRs couple with several different signaling pathways modulating various G-proteins (Fig. 1). Histamine H1R The H1R, including many other biogenic amine receptors, is one of the GPCR family members (see for a complete list e.g. http://www.gpcr.org/7tm/ or http://tools.gpc

• Diabetes and atherosclerosis are paralleled by

  2022-03-31

  

  Diabetes and atherosclerosis are paralleled by impaired wound healing and endothelial angiogenesis in the periphery, which cause severe complications and mainly occur as a result of the elevated circulating levels of glucose and free fatty acids. Yuan et al. recently showed that palmitic NIBR189 in

• br Conclusion br Author contributions br Ethics approval br

  2022-03-31

  

  Conclusion Author contributions Ethics approval Competing interests Introduction VHL is a well-known tumor suppressor and works as a target recruitment subunit of an E3 ubiquitin ligase complex that recruits hydroxylated hypoxia inducible factor α (HIF-α) for proteasomal degradation u

• BIBR 1532 br Concluding remarks br Conflict of interest stat

  2022-03-31

  

  Concluding remarks Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank all the present and former members in our laboratory for their contributions to

14688 records 448/980 page Previous Next First page 上5页 446447448449450 下5页 Last page