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NeuroHIV is initiated by HIV crossing the blood
2022-08-11
NeuroHIV is initiated by HIV crossing the blood–brain barrier (BBB) to enter the CNS. This is thought to occur primarily via the transmigration of infected CD14+CD16+ monocytes (Williams, 2014), using the monocytes as “Trojan Horses” (Peluso, 1985), although some studies suggest alternate routes of
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br Introduction Ovarian cancer patients have the highest mor
2022-08-11
Introduction Ovarian cancer patients have the highest mortality rate amongst patients with gynecologic cancers. The 10-year survival rate of ovarian cancer patients is Cy5 RNA with BRCA1/2 mutation [2]. Several studies have indicated the role of dysregulation of histone methylation in carcinogen
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Materials and methods br Results and
2022-08-11
Materials and methods Results and discussion Acknowledgments This work was supported in part by the Japan Society for the Promotion of Science KAKENHI Grants JP21300174 and JP25282144 (H.K.). Introduction Epigenetic modifications of histones, such a lysine acetylation, play a key role in
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br Materials and methods br Results br Discussion
2022-08-11
Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either Azithromycin Dihydrate H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize the
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Hh signaling pathway plays an
2022-08-11
Hh signaling pathway plays an essential role in the regulation of invertebrate and vertebrate tissue development and metabolic homeostasis. Components of Hh signaling pathway have been identified in succession, including Hh ligands, membrane protein receptors, cytoplasmic components and transcriptio
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Eastern Guangdong is a Teochew dialect
2022-08-11
Eastern Guangdong is a Teochew dialect area. We found that subtype 1b (3.1%) in this region was significantly lower than in other areas. Subtype 1b began its spread from the central part of China out into the whole country through illegal blood donation in the mid-1990s (Lu et al., 2013) and is now
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While phosphorylation site motifs are typically described in
2022-08-11
While sars-cov site motifs are typically described in terms of residues that promote phosphorylation, negatively selected residues can also be an important component of substrate recognition. Such ‘forbidden’ resides can act as a filter to prevent phosphorylation of a site by the ‘wrong’ kinase, whi
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The relaxant response to carperitide was influenced neither
2022-08-11
The relaxant response to carperitide was influenced neither by the removal of the endothelium nor by treatment with the nitric oxide synthase inhibitor or nitric oxide scavenger. This result was to be expected as previous studies showing that the vasodilator action of atrial natriuretic peptide is e
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hoechst 33342 Under most circumstances NO is a
2022-08-11
Under most circumstances, NO is a potent endogenous vasodilator. Therefore, its involvement in an endothelium-dependent contraction seems paradoxical, to say the least. Soluble guanylyl cyclase (sGC) is the major downstream target of NO; its inhibition results in the lack of vasoconstrictor response
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On the basis of the structure of
2022-08-11
On the basis of the structure of the Rab35/ACAP2 complex, the authors identified Thr76 in switch II of Rab35 as one key specificity determinant (Lin et al., 2019). The crystal structure shows that the hydroxyl group of Thr76 forms a BRD 7552 with Asp756 in ACAP2, while the methyl group is a part of
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Curcumin is the active ingredient extracted from
2022-08-11
Curcumin is the active ingredient extracted from the natural medicine turmeric rhizome (Goel et al., 2008, Aggarwal and Harikumar, 2009). Studies have shown that curcumin has anti-tumor, anti-inflammatory, antioxidant and antimicrobial properties (Larsen et al., 2007, López-Lázaro, 2008). Although c
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In humans the effect of GnRH and hCG on trophoblast
2022-08-11
In humans, the effect of GnRH and hCG on trophoblast invasion was found to be mediated through extracellular matrix remodeling by facilitating the activity of MMP2 and MMP9 [13], [18], [44]. Both SCR 7 are collagenases that degrade extracellular matrix. In canines, this has not yet been investigate
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On the basis of their relative
2022-08-11
On the basis of their relative Glu transport rates and anion currents, EAATs group into two functionally distinct classes, EAAT1–3 being efficient Glu transporters with small associated macroscopic anion currents and EAAT4–5 low-capacity transporters with predominant anion conductance [18]. The diff
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By regulation of synaptic glutamate
2022-08-10
By regulation of synaptic glutamate concentration, glutamate transporters play an important role in limiting glutamate signaling and controlling the activation of glutamate receptors (Rimmele and Rosenberg, 2016). Reduced glutamate transport is thought to underlie the pathogenesis of numerous neurol
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(±)-J 113397 br Vesicular glutamate transporters VGLUTs
2022-08-10
Vesicular glutamate transporters (VGLUTs) Conclusions Due to the molecular cloning of EAAT and VGLUT subtypes, a better understanding of the functional properties of these carriers has been elucidated over the last few years. In the case of the EAATs, specific blockers, such as trans-2,4-PDC,
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