• A characteristic of iron present

  2024-02-01

  

  A characteristic of iron present in brain fluids is considerable differences between measured values of ferritin and transferrin and the total iron content value (Table 1). Variation of the latter is compatible with differences in individual metabolisms. However differences between total iron conten

• br Regulation of AHR Activity AHR

  2024-02-01

  

  Regulation of AHR Activity AHR activity is regulated in various ways. First, AHR protein levels are controlled via ubiquitin-mediated proteosomal degradation: Ligand binding induces AHR ubiquitination and subsequent degradation by the proteasome [5]. AIP, a component of the AHR chaperone complex,

• br The AHR functions in the immune system a tsunami

  2024-02-01

  

  The AHR functions in the immune system – a tsunami of exciting findings The research of recent years has convincingly established an important function of the AHR in linking chemical environmental cues to immune responses [21,22], and reviewed in [1,23]. As a side effect, a view of the AHR as “Th

• In conclusion we have shown

  2024-02-01

  

  In conclusion, we have shown that mGlu7 receptors negatively regulate α1-adrenergic receptor signalling in heterologous expression systems, lipid metabolism pathway tissue and living animals. This interaction might represent a protective mechanism aimed at restraining an excessive activation of nor

• However although in vitro studies in heterologous systems ha

  2024-02-01

  

  However, although in vitro studies in heterologous systems have provided very important indications of potential novel pharmacology, the studies with endogenous receptors in native tissues are essential to provide evidence for GPCR heteromerization in vivo and to confirm its physiological relevance.

• br Discussion Here we focused on

  2024-02-01

  

  Discussion Here, we focused on seven plant alkaloids extracted from yokukansan. These alkaloids individually inhibited 5-HT-mediated 5-HT3A and 5-HT3AB receptor currents weakly. Simultaneous administration of these alkaloids, however, inhibited the 5-HT3A and 5-HT3AB receptor currents strongly. T

• br Conflict of interest statement br Benign

  2024-02-01

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal PU-WS13 receptor in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellula

• Taniyama et al reported a female with

  2024-02-01

  

  Taniyama et al. reported a female with infertility who had a homozygous T-to-A transversion at nucleotide position g.2472 in exon 3 of the CYP17A1 gene (mutation Y201N) and decreased 17-hydroxylase and 17,20-lyase activities of 527 receptor was initiated using dexamethasone to control adrenal P prod

• br Expression of autotaxin in

  2024-02-01

  

  Expression of autotaxin in cancer Autotaxin (ATX) is a member of the family of NPPs (Nucleotides pyrophosphatases phosphodiesterases (NPP) family with a unique lysophospholipase D (lysoPLD) activity, allowing the synthesis of LPA from lysophospholipid precursors such as the lysophosphatidylcholin

• br Materials and methods br Results To explore

  2024-02-01

  

  Materials and methods Results To explore the potential role of autophagy in drug resistance, we firstly performed immunohistochemistry to compare the N,N-Dimethylsphingosine sale of p62 in paired primary, metastatic, and recurrent tumor tissues from 26 ovarian cancer patients. The expression o

• Aurora A overexpression is also related

  2024-02-01

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer Patchouli alcohol receptor [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene pro

• Phagosomes acquire some hydrolases early during their journe

  2024-02-01

  

  Phagosomes acquire some hydrolases early during their journey from the cell surface to lysosomes. An example for such hydrolase is cathepsin H which is most concentrated in the early phagosome at a pH of approximately 6.3 (Claus et al., 1998), the pH optimum of enzyme activity (Schwartz and Barrett,

• gamma-Glu-Cys receptor Neuropathic animals display increased

  2024-02-01

  

  Neuropathic animals display increased sensitivity to the anti-nociceptive effect of baclofen and whilst the number and affinity of GABAB gamma-Glu-Cys receptor in the dorsal horn are not altered (Smith et al., 1994; Zemoura et al., 2016), GABAB receptors subunits (B1 and B2) are both down-regulated

• Thiazole heterocycles constitute an interesting class of mol

  2024-01-31

  

  Thiazole heterocycles constitute an interesting class of molecules, which exhibit a broad spectrum of biological activity, including antifungal properties [[16], [17], [18], [19]]. Encouraged by our previous study that describes the activity of hydrazine-thiazole derivatives against C. gattii and C.

• br Under normal physiological conditions

  2024-01-31

  

  Under normal physiological conditions, the agonist binds to AT1R on the surface of the plasma membrane and activates the receptor, mediating downstream signaling. Then, activated AT1R is phosphorylated by protein kinase C (PKC) [13] or G protein coupled receptor kinases (GPKs, such as GRK2 [13], G

14266 records 172/952 page Previous Next First page 上5页 171172173174175 下5页 Last page