• We have previously shown that the human gonadotropins hLH an

  2024-07-15

  

  We have previously shown that the human gonadotropins hLH and hCG trigger a partly irreversible stimulation of intracellular cyclic AMP accumulation in mouse Leydig Tumor Melatonin (MLTC) in contrast to all other tested mammalian LHs and CG (Klett et al., 2016). In order to get a better insight in

• Another interesting interaction concerns NMDA preconditionin

  2024-07-15

  

  Another interesting interaction concerns NMDA preconditioning to protect against glutamate neurotoxicity. It has been shown that an A1R antagonist prevented neuroprotection evoked by NMDA preconditioning against glutamate-induced cellular damage in cerebellar granule cells. In this study, the functi

• As an alternative to chronic receptor blockade we have

  2024-07-15

  

  As an alternative to chronic receptor blockade, we have been targeting adenosine kinase (ADK) – an astrocyte-based enzyme that catalyses the phosphorylation of adenosine, as a means to modify erk pathway adenosinergic signalling (Boison, 2006, Etherington et al., 2009). Up-regulating ADK facilitate

• Aurora A overexpression is also related to the

  2024-07-15

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer luteolin receptor [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene products an

• br Introducing toll like receptors TLRs are the most

  2024-07-15

  

  Introducing toll like receptors TLRs are the most important receptors which are expressed on the cytoplasmic and internal vesicles membrane. They have a similar structure including a leucine-rich repeats (LRRs) domain which is out of 8-Azido-ATP receptor membrane, a hydrophobic transmembrane and

• To further investigate the role of cholesterol in the

  2024-07-12

  

  To further investigate the role of cholesterol in the Rh2-induced cytotoxicity, we then focused on the U937 cell line, which is cholesterol auxotroph and considered as a valuable model to study the importance of cholesterol in membrane structure and function (Billheimer et al., 1987), and used the e

• Apelin APJ triggers a variety of cellular signaling

  2024-07-12

  

  Apelin/APJ triggers a variety of cellular signaling pathways (Fig. 1). Recent studies from our laboratory showed that apelin-13 induces vascular smooth muscle cell (VSMC) proliferation by the upregulation of Cyclin D1 expression, which is involved in an ERK-dependent activation of Jagged-1/Notch3 si

• Coincident with APJ receptor several cell types in the

  2024-07-12

  

  Coincident with APJ receptor, several cell types in the body can synthesize apelin protein. For example, the highest apelin concentrations in the body have been found in the rat central nervous system, pituitary gland, lungs, cardiac muscle, gastrointestinal tract and mammary glands, with lower valu

• Additional support for a role of HMGN in enhancing

  2024-07-12

  

  Additional support for a role of HMGN1 in enhancing DNA repair comes from studies of transcription-coupled repair (TCR) in human cells. Lesions in the template strand of DNA induced by UV light stall the movement of RNA polymerase II (RNAPII) and interrupt transcription. Removal of these transcript

• Tumor tissues often experience hypoxia owing to accelerated

  2024-07-12

  

  Tumor tissues often experience hypoxia owing to accelerated growth rates of malignant cells, accumulation of metabolic products, disorganization of tumor blood vessels, and high interstitial fluid pressures (Makino et al., 2001). In response to AAD treatment, tumor vascular density often decreases t

• Introduction Cardiovascular disease is the principal cause o

  2024-07-12

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with am580 (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascular risk f

• br Role of AR in models of neointima formation

  2024-07-12

  

  Role of AR in models of neointima formation Investigations into the pathogenesis of lesion formation have often used acute models of mechanical damage to assess the mechanisms regulating the fibro-proliferative response to arterial injury. Models of acute injury used for this purpose include: lig

• br Discussion Missense mutations transversions

  2024-07-12

  

  Discussion Missense mutations (transversions) of the first nucleotide of the phenylalanine 1568 at position 1174 (F1174) of the anaplastic lymphoma kinase gene can result in substitutions to leucine or valine (F1174L/V) while missense mutation (transversion) of the second nucleotide of the pheny

• br Conclusion The HT receptor

  2024-07-12

  

  Conclusion The 5-HT receptor family is complex, and one may ask as does Bryan Roth et al. [205] whether this is useless naloxone hydrochloride (i.e. too much redundancy) or an embarrassment of the riches (i.e. many potential targets to choose from to affect normal or pathological function); molec

• While A Rs communicate mainly

  2024-07-12

  

  While A1Rs communicate mainly with the D1R subtype [36], A2AR and D2R interaction occurs mainly in basal ganglia. D2Rs colocalizes with A2ARs in this YM 155 area where they are preferentially localized postsynaptically in the soma and dendrites of GABAergic striatopallidal neurons [69]. This interac

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